https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Neurometabolic changes in multiple sclerosis: Fingolimod versus beta interferon or glatiramer acetate therapy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53309 .05). Compared to HCs, both RRMS cohorts showed volume changes in white matter (−13%), gray matter (−16%), and cerebral spinal fluid (CSF) (+17-23%), as well as reduced NAA (−17%, p =.001, hippocampus), (−7%, p =.001, PCG), and (−9%, p =.001, PFC). MRI/S metrics in three regions were moderately correlated with cognition and fatigue functions. Conclusion: While both treatment arms showed overall similar volumetric and neurometabolic profiles, longitudinal studies are warranted to clarify neurometabolic changes and associations with treatment efficacy.]]> Tue 21 Nov 2023 12:02:21 AEDT ]]> Altered in vivo brain GABA and glutamate levels are associated with multiple sclerosis central fatigue https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40208 Mon 01 Aug 2022 09:10:25 AEST ]]>